2016 Fiscal Year Final Research Report
Evaluation of the association between intracerebral insulin action and cognitive impairment in animal models of Alzheimer disease
| Project/Area Number |
26461341
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kumamoto University |
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Principal Investigator |
Kawashima Junji 熊本大学, 大学院生命科学研究部(医), 助教 (70467984)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 認知症 / インスリン抵抗性 |
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| Outline of Final Research Achievements |
We generated Alzheimer disease model mice with insulin resistance by mating IRS1 knockout (IRS1KO) mice with the Alzheimer disease model mice, APP23 transgenic (APP23Tg) mice or human mutant APP knock-in mice (NL/F KI), respectively.
It was not significant difference in cognitive function determined by Y maze test between APP23Tg(-)-IRS1 wild type (WT) mice, APP23Tg(+)-IRS1WTmice, APP23Tg(-)-IRS1KO mice and APP23Tg(+)-IRS1KO mice.
It was not significant difference in cognitive function determined by Y maze test between APPWT-IRS1WT mice, NL/F homo KI-IRS1WT mice, APPWT-IRS1KO mice and NL/F homo KI-IRS1KO mice.
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| Free Research Field |
代謝・内分泌
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