2016 Fiscal Year Final Research Report
The role of neural mechanism generated by intraportal GLP-1 in the physiological insulin secretion
| Project/Area Number |
26461347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | GLP-1 / インクレチン / インスリン分泌 / グルコース / 迷走神経 / 食行動 |
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| Outline of Final Research Achievements |
Glucagon-like peptide-1 and glucose in the portal vein have been known to generate neural information in the vagal nerve in rodents and shown to stimulate insulin secretion in the early phase. This study aimed to determine the role of the neural signal in the feeding and drinking behavior and insulinotropic effect in rats. Hepatic vagotomy reduced the amount of water drunk, but not food taken. The insulin secretion calculated as area under the curve following by glucose infusion (500 mg/kg) into the jugular vein was reduced around 20% in hepatic vagotomized rats. After the continuous infusion of glucose (10 mg/kg/min) and GLP-1 into the portal vein, the insulin secretions increased around 20% both in sham-operated and vagotomized rats and did not differ significantly between the groups with and without hepatic vagotomy.
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| Free Research Field |
インスリン分泌
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