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2016 Fiscal Year Final Research Report

The role of neural mechanism generated by intraportal GLP-1 in the physiological insulin secretion

Research Project

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Project/Area Number 26461347
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionKanazawa Medical University

Principal Investigator

NISHIZAWA Makoto  金沢医科大学, 医学部, 非常勤講師 (70278117)

Project Period (FY) 2014-04-01 – 2017-03-31
KeywordsGLP-1 / インクレチン / インスリン分泌 / グルコース / 迷走神経 / 食行動
Outline of Final Research Achievements

Glucagon-like peptide-1 and glucose in the portal vein have been known to generate neural information in the vagal nerve in rodents and shown to stimulate insulin secretion in the early phase. This study aimed to determine the role of the neural signal in the feeding and drinking behavior and insulinotropic effect in rats. Hepatic vagotomy reduced the amount of water drunk, but not food taken. The insulin secretion calculated as area under the curve following by glucose infusion (500 mg/kg) into the jugular vein was reduced around 20% in hepatic vagotomized rats. After the continuous infusion of glucose (10 mg/kg/min) and GLP-1 into the portal vein, the insulin secretions increased around 20% both in sham-operated and vagotomized rats and did not differ significantly between the groups with and without hepatic vagotomy.

Free Research Field

インスリン分泌

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Published: 2018-03-22  

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