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2016 Fiscal Year Final Research Report

Genes related to islet-specific autoimmune destruction and prevention of type 1 diabetes by regulating immune tolerance

Research Project

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Project/Area Number 26461349
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionKindai University

Principal Investigator

NOSO Shinsuke  近畿大学, 医学部, 講師 (90460849)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords1型糖尿病 / 免疫寛容 / β細胞
Outline of Final Research Achievements

This study aimed to clarify the mechanism of specific destruction of insulin-producing pancreatic beta cells and to prevent beta cell specific destruction. As for human study, genes related to organ specificity were clarified by association study of patients with type 1 diabetes, Graves disease and alopecia areata. Whole exome sequence analysis identified causal variant for familial, as well as sporadic type 1 diabetes in the Japanese population. As for mouse study, disruption of Mafa gene caused accelerated infiltration of lymphocytes into pancreatic islets, but suppressed spontaneous development of diabetes in the NOD mouse. Immunohistochemical staining by Foxp3 antibody suggested the involvement of a regulatory mechanism in benign insulitis.

Free Research Field

糖尿病

URL: 

Published: 2018-03-22  

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