2016 Fiscal Year Final Research Report
Regulation of bone metabolism by AKAP13
| Project/Area Number |
26461355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Chiba University |
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Principal Investigator |
KOIDE Hisashi 千葉大学, 医学部附属病院, 助教 (30507223)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 骨代謝 / 骨粗鬆症 / 骨リモデリング / 骨形成 |
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| Outline of Final Research Achievements |
AKAP13 is a protein that integrates various signaling such as mechanical stress and estrogen receptor activation. Analyses of animal and osteoblastic cells revealed that AKAP13 is involved in bone formation. AKAP13 plays an important role in the early stages of differentiation of osteoblasts, according to the expression analysis of the AKAP13 mRNA during differentiation of osteoblasts for bone formation, suggesting that AKAP13 may be an initiation trigger for osteogenic function and bone remodeling. We believe that analysis of AKAP13 and co-factor will lead to the development of new osteoporosis drugs the future.
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| Free Research Field |
骨代謝
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