Cardiac steatosis and arrhythmia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461360
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: University of Fukui
• Principal Investigator: Suzuki Jinya 福井大学, 学術研究院医学系部門(附属病院部), 講師 (20293417)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脂肪滴 / 脂肪毒性 / 脂肪心筋 / 不整脈 / 心房細動 / gap junction / connexin 43

Outline of Final Research Achievements

The association of cardiac steatosis and arrhythmia was studied using mouse model of cardiac steatosis. The transgenic (Tg) mice with cardiac-specific overexpression of perilipin (PLIN)2 was generated and analyzed. The Tg mice had 4-fold increased atrial triglyceride content and 3-fold higher incidence of prolonged atrial fibrillation. A gap-junction protein connexin 43 was displaced in atrial cardiomyocytes of Tg mice, and conduction velocity was delayed in the Tg atrium. Thus, cardiac steatosis might lead to arrhythmogenic remodeling of connexin 43.

Free Research Field

脂質代謝