2016 Fiscal Year Final Research Report
Regulation of macrophage foam cell formation and atherosclerosis by tissue-specific calpains
| Project/Area Number |
26461368
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Showa University |
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Principal Investigator |
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| Research Collaborator |
MIYAZAKI Takuro 昭和大学, 医学部生化学講座, 講師 (80398693)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | カルパイン / ピノサイトーシス / マクロファージ / 動脈硬化 |
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| Outline of Final Research Achievements |
Calpain-6, a member of calpain superfamily that has no proteolytic activity, was shown to be highly expressed in inflammatory macrophages and interact in the cytoplasm with CWC22, a factor that promotes nuclear translocation of exon-junction complexes, thereby interfering with nuclear translocation of CWC22. Association of CPNA6 with CWC22 led to suppression of mRNA splicing of various genes including Rac1 and acceleration of LDL pinocytosis by macrophages and subsequent development of atherosclerosis in mice.
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| Free Research Field |
生化学
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