Involvement of transcription elongation factor in transcriptional regulation by thyroid hormone and its receptor

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461378
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Matsushita Akio 浜松医科大学, 医学部附属病院, 助教 (50402269)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 甲状腺ホルモン / 核内受容体 / 転写制御 / 転写伸長反応

Outline of Final Research Achievements

Thyroid hormone (T3) binds to the thyroid hormone receptor (TR) in the nucleus and exerts hormonal action by regulating the transcriptional activity of the target gene. From the analysis of factors involved in transcriptional regulation of TR, we found that cyclin dependent kinase 9 (CDK9), which is a component of the positive transcriptional elongation factor (P-TEFb) that promotes mRNA synthesis reaction, binds to TR. By recruiting CDK9, TR promotes the transcriptional elongation reaction and enhances the transcriptional activity of the target gene.

Free Research Field

内分泌代謝