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2016 Fiscal Year Final Research Report

Epitope-specific therapy for Graves' disease with immune-modulating peptides and siglec ligands

Research Project

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Project/Area Number 26461385
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Endocrinology
Research InstitutionWakayama Medical University

Principal Investigator

Inaba Hidefumi  和歌山県立医科大学, 医学部, 講師 (70447770)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywordsバセドウ病 / TSH受容体 / HLA / T細胞
Outline of Final Research Achievements

The aim of this study is 1) to elucidate epitope presentation in Graves’ disease (GD), and 2) to establish epitope specific therapy for GD. We have reported that human TSH receptor (AA78-94) was an important epitope. Therapeutic role of the mutant human TSH receptor peptide: 37m, was evaluated in this study. GD model of HLA-DR3 transgenic mice was treated with 37m. The thyrotoxicosis was improved, TRAb production was suppressed, and proportion of regulatory T-cells in the spleen was increased. Therefore, immune-regulatory effects of 37m were observed.

Free Research Field

内分泌学

URL: 

Published: 2018-03-22  

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