Identification of causative genes of spontaneous dwarf mice and analysis of glucose metabolism

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461388
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Kurume University
• Principal Investigator: SATO TAKAHIRO 久留米大学, 分子生命科学研究所, 准教授 (50368883)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 矮小 / 抗肥満 / 高耐糖能

Outline of Final Research Achievements

In this study, we focused on spontaneously derived dwarf mutant mice. Since this mouse was characterized as anti-obesity and high glucose tolerance, it was considered to be a different mouse from known dwarf mutant mouse. Therefore, we aimed to identify causative genes by gene mapping analysis and next generation sequencing analysis. In addition, abnormal pathways related to obesity and glucose metabolism were also examined by PCR array analysis. Based on the above studies, the Crebbp gene of chromosome 16 was selected as a mutation candidate gene of this dwarf mutant mouse.

Free Research Field

内分泌学

Academic Significance and Societal Importance of the Research Achievements

この研究では、突然変異によって生まれた体の小さいマウスについてその原因となる遺伝子を調べ、どのような遺伝子異常があるのかを明らかにした。さらに、このマウスは、高脂肪食を食べても肥満しにくく、砂糖水を飲んでも血糖値が上がりにくいという特徴を持つことも見出した。したがって、このマウスを利用した研究から、メタボリックシンドロームの発症メカニズムの一端を明らかにすることが期待される。