Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461393
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: HOSODA HIROSHI 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (40359807)
• Co-Investigator(Renkei-kenkyūsha): KANGAWA KENJI 国立循環器病研究センター研究所, 研究所長 (00112417)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 血管内分泌学

Outline of Final Research Achievements

The aim of this study was to investigate the mechanism of atrial natriuretic peptide (ANP) in the prevention of cancer metastasis.
We have previously reported that ANP treatment during the perioperative period reduces inflammatory response and has a prophylactic effect on postoperative cardiopulmonary complications in lung cancer surgery.
ANP is known to bind specifically to guanylyl cyclase-A (GC-A) receptor. In mouse models, metastasis of GC-A-nonexpressing tumor cells to the lung was increased in vascular endothelium-specific GC-A knockout mice and decreased in vascular endothelium-specific GC-A transgenic mice compared with control mice. ANP inhibited the adhesion of cancer cells to pulmonary arterial and micro-vascular endothelial cells by suppressing the E-selectin expression that is promoted by inflammation. These results suggest that ANP prevents cancer metastasis by inhibiting the adhesion of tumor cells to inflamed endothelial cells.

Free Research Field

ペプチド化学