2016 Fiscal Year Final Research Report
Analysis of the mechanism of myelofibrosis with Smad3 knock out mice
| Project/Area Number |
26461398
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOKOTE Koutaro 千葉大学, 大学院医学研究院, 教授 (20312944)
IWAMA Atsushi 千葉大学, 大学院医学研究院, 教授 (70244126)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 骨髄線維症 / TGFβ |
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| Outline of Final Research Achievements |
We analyzed the mechanism of myelofibrosis with TEL-Lyn fusion gene and Smad3 knockout mouse. In vitro study using leukemia cell line and TEL-Lyn fusion gene failed to show overexpression of TGF-b. We are planning TGF-b expression analysis with iPS cell derived megakaryocyte.
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| Free Research Field |
血液学
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