2016 Fiscal Year Final Research Report
A role of the platelet activation receptor CLEC-2 in rheumatoid arthritis: a possible target protein for an anti-rheumatic drug
| Project/Area Number |
26461399
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Research Collaborator |
SASAKI Tomoyuki
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | CLEC-2 / 血小板 / 関節リウマチ / ポドプラニン / 滑膜細胞 |
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| Outline of Final Research Achievements |
It has been reported that podoplanin, a ligand of the platelet activation receptor CLEC-2, is expressed on synovial cells in the joint of patients with rheumatoid arthritis. In the present study, we investigated a role of CLEC-2 in thrumatoid arthritis.
The extent of experimental arthritis is significantly decreased in CLEC-2-deficient bone marrow-chimeric mice. Podoplanin stimulation by recombinant CLEC-2 increased inflammatory cytokines and cell proliferation.
We proposed that platelets are leaked from hyper-permeabilized capillaries during inflammation and that the interaction between platelet CLEC-2 and podoplanin in synovial cells exacerbate arthritis by inflammatory cytokines and cell proliferation.
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| Free Research Field |
血栓止血学
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