2016 Fiscal Year Final Research Report
Molecular pathogenesis of beta1 tubulin disorders
| Project/Area Number |
26461413
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | National Hospital Organization Nagoya Medical Center |
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Principal Investigator |
Kunishima Shinji 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, 室長 (60373495)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 巨核球 / 血小板 / 微小管 / チューブリン |
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| Outline of Final Research Achievements |
TUBB1/Tubb1 mutations identified in congenital macrothrombocytopenia of human, dog and big cats were functionally analyzed and classified in 1) abnormal oligomeric aggregation and the disruption of microtubule structure, 2) expression-level dependent abnormal microtubule structure and 3) normal microtubule structure (functional polymorphisms). The former type of mutation resulted in the decreased expression ofα tubulin and G1 arrest leading to the inhibition of cellular proliferation.
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| Free Research Field |
血栓止血
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