2016 Fiscal Year Final Research Report
Elucidation of pathogenic mechanism of adult T-cell leukemia induced by abnormal ROS regulation
| Project/Area Number |
26461417
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ATL / HTLV-1 / USP10 |
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| Outline of Final Research Achievements |
Adult T-cell leukemia (ATL) is an aggressive hematologic malignancy of poor prognosis caused by human T-cell leukemia virus type 1 (HTLV-1), and it is imperative to develop therapeutic drugs for chemotherapy against ATL. As arsenite or proteasome inhibitor bortezomib induce cell death in HTLV-1-infected T-cells, antitumor effect on ATL can be expected by using these drugs. In this study, we identified that ubiquitin-specific protease 10 (USP10) confers drug resistance phenotype to HTLV-1-infected T-cells. Based on this result, we are currently attempting to identify cellular defense mechanism against drug treatment that USP10 is involved.
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| Free Research Field |
ストレス応答、ウイルス学
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