The role of integrin alpha 8 in the pathogenesis of multiple myeloma

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461420
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Osaka University
• Principal Investigator: ICHII Michiko 大阪大学, 医学系研究科, 寄附講座助教 (30633010)
• Co-Investigator(Renkei-kenkyūsha): YOKOSAKI Yasuyuki 広島大学, 保健管理センター, 准教授 (80210607)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 骨髄腫 / インテグリン

Outline of Final Research Achievements

The purpose of this study is evaluating the role of integrin alpha 8 in the pathogenesis of multiple myeloma. It is reported that human plasma cells express integrin alpha 8. First, we analyzed the expression of integrin alpha 8 on myeloma cells. As a result, not all of myeloma cell lines express integrin alpha 8. In contrast, the expression of integrin alpha 8 was detected in myeloma cells derived from patient bone marrow and peripheral blood. The effect of integrin alpha 8 on proliferation and resistance against cytotoxic drugs seemed similar between integrin alpha 8 positive and negative myeloma cell lines. These results indicated that integrin alpha 8 might be useful for evaluating residual disease during treatment.

Free Research Field

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