Clinical features and genetic alterations of MDS among atomic bomb survivors.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461426
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Nagasaki University
• Principal Investigator: MIYAZAKI Yasushi 長崎大学, 原爆後障害医療研究所, 教授 (40304943)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 骨髄異形成症候群 / 原爆被ばく / 放射線 / 染色体異常 / ゲノム異常

Outline of Final Research Achievements

We studied clinical features and genome alterations of MDS among atomic bomb survivors. We found that the frequency of abnormal karyotype was significantly higher in MDS among survivors exposed at closer distance from hypocenter, especially karyotypes related to poor prognosis, such as complex karyotypes. However, there was no significant difference in overall survival, cumulative incidence of leukemia, or leukemia-free survival by the distance from hypocenter. These findings suggested that the impact of cytogenetic abnormality could be different between de novo MDS and MDS among survivors. We analyzed genome alteration in a rare case of MDS that transformed into acute lymphoblastic leukemia, in which new genome alterations were obtained at transformation.

Free Research Field

血液内科学