2016 Fiscal Year Final Research Report
Low-dose IL-2 combined with PD-1 blockade separates GVHD and GVL effect.
| Project/Area Number |
26461449
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 造血幹細胞移植 / 制御性T細胞 / GVHD / 免疫寛容 |
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| Outline of Final Research Achievements |
We previously reported that low-dose IL-2 can induce immune-tolerance with the increase of Treg. However, Treg increase might reduce GVL effect. Therefor, we need to develop the technique to regulate Treg homeostasis during low-dose IL-2 therapy. In this study, our murine study and human subject analysis clearly demonstrated that PD-1 signaling has indispensable role for Treg homeostasis during IL-2. Our results might provide important information for the development of the Treg-based immune therapy for patients after HSCT.
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| Free Research Field |
造血幹細胞移植学
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