The role of myeloid derived suppressor cells and transcription factor GATA2 in collagen disease related pulmonary arterial hypertension

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461457
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Tohoku University
• Principal Investigator: Shirota Yuko 東北大学, 大学病院, 助教 (20455819)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 肺動脈性肺高血圧症 / 転写因子GATA2

Outline of Final Research Achievements

We investigated the role of transcription factor GATA-2 and Myeloid derived suppressor cell (MDSC) and macrophage in pulmonary arterial hypertension (PAH). 1) In human pulmonary tissues, there are more GATA2+CD68+ macrophage cell infiltrated in PAH compared to healthy control. 2) Peripheral MDSC subsets were significantly increased in human PAH compared to controls. 3) We established GATA2 conditional knock out mice, and those mice and control mice were induced PAH in hypoxia condition. Right ventricle hypertrophies were highly occurred in controls compared to GATA2-KO. The pulmonary arteries remodeling was equally occurred in both group. On the other hand, there were more inflammatory cells infiltrated in GATA-2 KO. In human PAH, GATA2 expression might be upregulated, however, we could not have definite tendency in inducing PAH in GATA2-KO model. We would like to investigate additional experiments.

Free Research Field

膠原病