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2016 Fiscal Year Final Research Report

The ubiquitylation system as a potential therapeutic target for rheumatic diseases

Research Project

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Project/Area Number 26461468
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionYokohama City University

Principal Investigator

YOSHIMI Ryusuke  横浜市立大学, 附属病院, 助教 (70585265)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords膠原病学
Outline of Final Research Achievements

The up-regulation of type I interferon (IFN)-inducible genes, which is called “IFN signature”, is observed in several rheumatic diseases, such as systemic lupus erythematosus (SLE). In this study, we investigated the role of TRIM family proteins in the “IFN signature” using peripheral blood mononuclear cells (PBMC) from patients with the rheumatic diseases. Although the mRNA level of TRIM21 was significantly higher in PBMC from patients with SLE as compared to healthy controls (HC), proteasome-dependent degradation of IRF proteins, which are substrates of TRIM21, was impaired in SLE. The expression level of TRIM27 mRNA was significantly lower in PBMC from patients with SLE as compared to HC. The expression level of TBK1 protein, which is the substrate of TRIM27 and promotes type IFN production, was upregulated in SLE. These results suggest that dysregulation or dysfunction of TRIM family proteins leads to the overproduction of type I IFNs in SLE.

Free Research Field

医歯薬学

URL: 

Published: 2018-03-22  

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