2016 Fiscal Year Final Research Report
The regulation mechanisms of chronic pain via ER-stress pathway in fibromyalgia
| Project/Area Number |
26461476
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 線維筋痛症 / 疼痛 |
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| Outline of Final Research Achievements |
Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology. Then the decisive treatments for FM have not been established. We focused on ER stress signals and function of mitochondria in FM. In this study, we attempted to establish the neuron specific synoviolin (SYVN1) deficient mice and an inflammation model mice in the central nerves system (CNS) with HPV vaccine as pathological animal models of FM. Then we analyzed the lesions and pathological mechanisms of FM using these mice and tissues derived from patients with FM. The SYVN1 deficient mice had the morphological abnormality in the CNS. The mouse vaccinated with HPV vaccine showed neurological phenotypes that include low responsiveness of the tail reflex and locomotive mobility. Pathological analyses of these mice revealed the damage to the hypothalamus. These data indicated that these model mice were useful for analyses of FM pathology and the hypothalamus could have important roles for symptoms of FM.
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| Free Research Field |
分子生物学
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