2016 Fiscal Year Final Research Report
The study of bone destruction mechanism of rheumatoid arthritis by synoviolin
| Project/Area Number |
26461478
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
YAGISHITA Naoko 聖マリアンナ医科大学, 医学研究科, 講師 (40367389)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 遺伝子 / タンパク質 / 動物 / 関節リウマチ / 滑膜細胞 / 小胞体関連分解 / 骨代謝 |
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| Outline of Final Research Achievements |
The symptoms of rheumatoid arthritis (RA) are based on the many processes. We recently cloned Synoviolin as an overexpressing molecule in rheumatoid synovium, and has been verifying its critical roles in RA. In this study, we investigated the role of synoviolin in bone and cartilage using Synoviolin conditional knockout mice and showed that Synoviolin has a crucial role in cartilage.
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| Free Research Field |
分子病態学
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