2016 Fiscal Year Final Research Report
Investigation on T cell-dependent, IgE-independent bronchoconstriction mechanism
Project/Area Number |
26461497
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Collagenous pathology/Allergology
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Research Institution | Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital |
Principal Investigator |
MORI AKIO 独立行政法人国立病院機構(相模原病院臨床研究センター), 先端技術開発研究部, 部長 (80251247)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 喘息 / T細胞 / 平滑筋 / 遅発型反応 / 喘息モデル |
Outline of Final Research Achievements |
T cell-induced bronchoconstriction in asthma is studied in the present study. Antigen-specific T cell clones were established from PBMC obtained from asthmatic donors, and the culture supernatants of T cell clones were analyzed in terms of human bronchial smooth muscle cells-embedded collagen gels. In addition, murine antigen-specific T cell clones and murine asthma model was established to clarify immunological mechanisms of T cell-induced bronchoconstriction. Lastly, we tried to analyze guinea pig bronchial ring for pharmacological characterization of this response.
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Free Research Field |
アレルギー学
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