2016 Fiscal Year Final Research Report
Spontaneous clearance of Hepatitis C virus infection
| Project/Area Number |
26461506
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
|
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| Research Collaborator |
IKEZAKI Hiroaki
HIRAMINE Satoshi
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Hepatitis C virus / Interleukin 28B / Spontaneous clearance / Japanese population / African Americans |
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| Outline of Final Research Achievements |
Hepatitis C virus (HCV) infection is a serious global health problem. Genome-wide association studies have revealed several single-nucleotide polymorphisms around
interleukin 28B (IL28B) that are strongly associated with HCV clearance by antiviral treatment. Both the favorable IL28B rs8099917 genotype and female sex were associated with the spontaneous clearance of HCV in the Japanese population. A long TA repeat in the promoter region ofIL28B was also associated with spontaneous HCV clearance. Although its efficacy may be limited in Japanese population because of its allele distribution, this novel genetic factor will be useful for predicting HCV clearance especially for the African Americans.
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| Free Research Field |
Infectious diseases
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