Airway inflammation in response to environmental exposure: infection and cigarette smoking

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461514
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Juntendo University
• Principal Investigator: Wada Hiroo 順天堂大学, 医学(系)研究科(研究院), 准教授 (50407053)
• Co-Investigator(Renkei-kenkyūsha): GOTO Hajime 杏林大学, 医学部, 教授 (80134617)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: COPD / 環境曝露 / 呼吸器病学

Outline of Final Research Achievements

The role of IL-17 in an inflammatory reaction to cigarette smoke exposure was investigated, using IL-17 deficient mice. IL-17 deficient mice showed that neutrophilic inflammation was restored in short-term exposure, and subsequently that the emphysematous change was restored after long-term exposure, in comparison with the wild-type mice. This suggested that IL-17 plays a crucial role in an inflammatory reaction to cigarette smoke exposure, and thus a possible molecular target in the therapeutic strategies to cigarette-smoke associated airway disorder, such as COPD.

Free Research Field

公衆衛生学