2016 Fiscal Year Final Research Report
Precise diagnostic trace elemental imaging by synchrotron-generated X ray
| Project/Area Number |
26461534
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 微量元素異常 / 遺伝病 / 銅 / ウィルソン病 / メンケス病 / ヘモクロマトーシス / 放射光Ｘ線 / 組織元素イメージング |
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| Outline of Final Research Achievements |
Inherited metabolic disorders of trace elements are rare, but difficult to diagnose clinically as well as pathologically. We tried to incorporate synchrotron-generated brilliant X-ray to pathological examination and successfully detected trace elements in tissue sections; such as copper, iron and zinc. We also achieved to simultaneously create two-dimensional elemental maps. These elemental disorders, that have been impossible to capture pathological study, are now readily diagnosing by synchrotron X-ray fluorescence analysis. Now, we open the door to elemental pathology. The diagnosis and pathogenesis of abnormality in trace elements can be analyzed with a new aspect.
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| Free Research Field |
医歯薬学
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