2016 Fiscal Year Final Research Report
Evaluation of blood myokine levels in obese childre with metabolic symdrome
| Project/Area Number |
26461535
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 小児肥満 / メタボリックシンドローム / マイオカイン / IL-6 / アイリシン |
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| Outline of Final Research Achievements |
We investigated the relationship between serum IL-6 and irisin levels, anthropometries and MS-related components in Japanese obese children. 85 obese Japanese children were enrolled. The relationship between serum IL-6 and irisin levels and anthropometries, MS-related components were evaluated. Among 85 obese children, 37 were diagnosed as morbidly obese. The serum IL-6 and irisin levels were decreased in morbidly obese group, compared with mild to moderate obese group, but not significant. Among 85 obese children, 30 were diagnosed as MS. The serum levels of IL-6 and irisin levels were decreased in MS group, compared with non-MS, but not significant. By univariate linear regression analysis, serum levels of IL-6 were positively correlated with AST, ALT and inversely positively correlated with apoA1. Serum levels of myokines, might be associated with development of MS in obese children. Further investigation will be needed.
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| Free Research Field |
小児内分泌、代謝
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