2016 Fiscal Year Final Research Report
Novel diffusion MRI analyses of brain lesions in children
| Project/Area Number |
26461551
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 拡散MRI / 拡散カトーシス画像 / 拡散テンソル画像 / 微細構造 |
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| Outline of Final Research Achievements |
We performed analyses of microstructural abnormalities of the brain in children with various neurological diseases by using next generation diffusion MRI imaging technique. By applying a 32-axis gradient magnetic field and 3 b values using a 3 Tesla MRI apparatus, we determined the protocol to obtain appropriate diffusion kurtosis images. We attempted to detect microstructural abnormalities of the brain in children with various neurological diseases by means of fractional anisotropy (FA) and mean kurtosis (MK) values as parameters. In particular, many cases of perinatal brain damage could be examined. As a result, there was a resolution limit in diffusion kurtosis images, and it became clear that its detection capability was insufficient. Statistical analysis by tract-based spatial statistics revealed that there is a correlation between MK values and neurological outcome.
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| Free Research Field |
小児神経学
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