2016 Fiscal Year Final Research Report
Mechanisms of Onset of Human Parechovirus Type 3 Infection in Neonates -A role of Transfer Antibodies-
| Project/Area Number |
26461569
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Niigata University |
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Principal Investigator |
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| Research Collaborator |
Aizawa Yuta
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ヒトパレコウイルス3型 / 新生児 / 移行抗体 / 敗血症 / 髄膜脳炎 |
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| Outline of Final Research Achievements |
Human parechovirus type 3 (HPeV3) is an emerging infection causing sepsis and meningoencephalitis in neonates and young infants. To understand the pathogenesis of HPeV3 infection, we measured 1) neutralizing antibody titers to HPeV1, HPeV3, and HPeV6 in cord blood samples from term infants and 2) 45 neonates and young infants diagnosed as having severe HPeV3-related diseases. As results, antibodies to HPeV1, HPeV3, and HPeV6 in cord blood samples were similar among 3 types (P = 0.17), and 40% of samples was low titers against HPeV3. Among the patients, 42/45 (93%) had a neutralizing antibody titer to HPeV3 <1:4, and the remaining 3/45 (7%) had low neutralizing antibody titers, ie, <1:16 at disease onset. Subsequent antibody titers increased to >1:512 in all patients who underwent follow-up examinations at ages 3 months and 6 months. These results indicate that transfer antibodies are important in neonates and young infants with severe HPeV3-related diseases.
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| Free Research Field |
小児感染症
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