Comprehensive analysis using metabolome profiling for investigating new biomarkers associated with the pathophysiology of acute viral encephalopathy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461581
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Nagoya University
• Principal Investigator: Ito Yoshinori 名古屋大学, 医学系研究科, 准教授 (20373491)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 急性脳症 / ヒトヘルペスウイルス6型 / インフルエンザ / バイオマーカー / キヌレニン / キノリン酸

Outline of Final Research Achievements

Influenza-associated encephalopathy and human herpesvirus 6 encephalopathy are common forms of acute encephalitis/encephalopathy in Japan. Comprehensive metabolome profiling, which can analyze around 3,000 metabolites, was applied to discover new aspects of its disease pathophysiology and new potential biomarkers.
As a result of metabolome profiling, kynurenine and quinolinic acid were selected as potential metabolites associated with the pathophysiology of those two encephalopathies. Trans-endothelial electrical resistance of the in vitro blood brain barrier model was significantly decreased after quinolinic acid treatment in culture.

Free Research Field

小児感染症