2016 Fiscal Year Final Research Report
Investigation of host factors for severe influenza virus infection
| Project/Area Number |
26461585
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
|
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| Research Institution | Okayama University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | インフルエンザ / VNN1 |
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| Outline of Final Research Achievements |
Results: (i) Increased expression of IL-11, Fas L, Angiotensin II receptor genes was observed in vascular endothelial cells, when influenza virus infected the respiratory epithelium (in vitro）. It was thought to be an influenza virus specific response. (ii) VNN1 was newly identified as a gene involved in influenza virus replication in the respiratory epithelium. VNN1 is an enzyme that hydrolyzes pantetheine, and it was found that cysteamine which is a degradation product of pantetheine, has a virus replication inhibiting action.
|
| Free Research Field |
小児感染症
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