2016 Fiscal Year Final Research Report
Transmission of virulence and antibiotic resistance genes among Enteroaggregative Escherichia coli strains isolated from children
| Project/Area Number |
26461589
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Ｅｓｃｈｅｒｉｃｈｉa coli / EAEC / ESBL / K1 capsule |
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| Outline of Final Research Achievements |
We performed phylogenetic analysis of entereaggregative Escherichia coli (EAEC) 167 strains isolated in Japan and found five major clones including an EAEC/UPEC (uropathogencic E. coli) hybrid clone O25:H4/ST131 possessing extend-spectrum beta-lactamase (ESBL) blaCTX-M gene. The incidence of blaCTX-M-positive strains among E. coli isolates from diarrheal children increases since 2013, and reached to 10.7% in 2013. Pathogenic genes among blaCTX-M-positive E. coli strains were as follows: EAEC aggR, 19%; EPEC (enteropathogenic E. coli) eae, 0.01%; K1 capsule gene neuC, 15.1%. These results suggest the pronounced horizontal transfer of blaCTX-M and pathogenic genes.
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| Free Research Field |
感染症学
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