2017 Fiscal Year Final Research Report
Relationship between NIPA and MYCN
| Project/Area Number |
26461601
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | National Defense Medical College |
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Principal Investigator |
KAWAGUCHI HIROYUKI 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 小児科学, 准教授 (00313130)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | neuroblastoma / NIPA (ZC3HC1) / MYCN |
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| Outline of Final Research Achievements |
No functional relevance between NIPA (ZC3HC1) protein and MYCN protein could be proved. Neuroblastoma cell lines could be divided into two groups: ones which show suppressed proliferation by silencing NIPA (group A; SK-N-DZ, CHP-212, GOTO, SK-N-MC), and ones which do not (group B; SK-N-AS, KELLY, TGW, IMR-32, NB-39nu). No common biological feature in these two groups could not be specified. Although 49 genes that show upregulation or down regulation with silencing were identified, no significant impact on pathogenesis of neuroblastoma could not identified.
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| Free Research Field |
小児腫瘍学
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