2017 Fiscal Year Final Research Report
DNA methylation of microRNA genes in gastrointestinal mucosa from pediatric patients with chronic gut inflammation
Project/Area Number |
26461605
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
|
Research Institution | Shinshu University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
坂下 一夫 信州大学, 医学部附属病院, 特任研究員 (10345746)
日高 奈緒 信州大学, 医学部附属病院, 医員 (30626023)
加藤 沢子 信州大学, 医学部附属病院, 助教(診療) (80762814)
|
Research Collaborator |
KUSAKARI Mai 信州大学, 医学部附属病院, 医員
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Keywords | methylation / Helicobacter pylori / ulcerative colitis / epigenetic |
Outline of Final Research Achievements |
We evaluated the methylation status of miR124a in pediatric patients with Helicobacter pylori infection or ulcerative colitis. The prevalence of methylation of gastric mucosa was greater in patients with active Helicobacter pylori gastritis and decreased after eradication therapy. In the rectal mucosa with ulcerative colitis in children, the methylation level was not increased irrespective of disease duration or clinical severity.
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Free Research Field |
小児消化器
|