2016 Fiscal Year Final Research Report
Potential role of subplate neuronal damage on the fetal cortical development
| Project/Area Number |
26461628
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | サブプレート / 胎児 / 脳白質損傷 / 脳回形成 / MRI |
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| Outline of Final Research Achievements |
Subpalate layer is located between cerebral cortex and subcortical white matter only in the fetus. Since the subplate neurons are vulnerable against inflammation and oxidative stress, subplate injury in the developing brain might cause abnormal cortical development or disturbed gyral formation. Using our established model of cerebral white matter injury in the ovine fetus, we could determine the subplate layer in the MRI, where the subplate neuronal cells were detected in the immunohistochemistry against anti Nurr-1 antibody.
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| Free Research Field |
医歯薬学 内科系臨床医学 胎児・新生児医学
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