Regulation of energy metabolism between brain and periferal organs; molecular mechanism of stress-induced life style-related diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461636
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kagawa University
• Principal Investigator: MIKI TAKANORI 香川大学, 医学部, 教授 (30274294)
• Co-Investigator(Kenkyū-buntansha): 太田 健一 香川大学, 医学部, 助教 (50403720) ; 鈴木 辰吾 香川大学, 医学部, 講師 (50451430) ; 割田 克彦 鳥取大学, 農学部, 准教授 (40452669) ; 横山 俊史 神戸大学, 農学研究科, 助教 (10380156) ; 日下 隆 香川大学, 医学部, 教授 (50274288)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: ストレス / 脳発達 / 生活習慣病 / 肥満 / エネルギー代謝 / 末梢臓器

Outline of Final Research Achievements

This study was carried out to examine the effects of early postnatal maternal separation stress on the developmental crosstalk between the brain and peripheral energy-related organs. Our study can obtain insight understanding etiological mechanisms of life style-related diseases, such as obesity.　Maternally separated rats showed abnormal alterations in neurotrophic factor expressions, their signal transduction systems and synapse structure protein phosphorylations. Furthermore, maternal separation stress affected various enzymes that involves in lipid metabolism. Examination on gut microbiota in these animals showed a disturbance in microbial composition leading to cause abnormal metabolism and/or nutrition. Our study showed that maternal separation stress during early postnatal life can affect the functions of both brain and peripheral organs that causes obesity in later life.

Free Research Field

発達神経科学