2016 Fiscal Year Final Research Report
Glutamate Promotes Contraction of the Rat Ductus Arteriosus
| Project/Area Number |
26461639
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Yokohama City University |
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Principal Investigator |
FUJITA Shujiro 横浜市立大学, 医学研究科, 共同研究員 (90381516)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 動脈管開存症 / グルタミン酸 / アミノ酸 |
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| Outline of Final Research Achievements |
Patent ductus arteriosus is a frequent and serious disease affecting the life and developmental prognosis of premature infants, but the influence of amino acids on the closure of the ductus arteriosus has not been clarified so far. This study revealed that glutamate induces rat ductus arteriosus contraction due to noradrenaline production. Administration of glutamate may be useful for prevention of patent ductus arteriosus in human premature infants.
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| Free Research Field |
新生児学
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