2017 Fiscal Year Final Research Report
Clinical outcomes fed by individualized human milk fortification in extremely preterm infants
| Project/Area Number |
26461646
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Keywords | 超早産児 / 強化母乳栄養 / 個別化強化 / 蛋白質添加 / 発育 |
|---|
| Outline of Final Research Achievements |
Extrauterine growth restriction (EUGR) is associated with poor neurodevelopmental outcome in extremely preterm and/or very low birth weight infants. EUGR is associated with inadequate protein intake. Individualized human milk fortification has two approaches, adjustable human milk fortification and targeted human milk fortification. However, it remained unknown which is better fortification to prevent EUGR. Our study aim is to compare the effects on postnatal growth during NICU stay among these two approaches. There were no differences in SD scores for body weight, body length (BL) and head circumference (HC) at term equivalent age among two individualized fortification regimens. By individualized fortification, not only body weight and HC but also BL was equal to the reference fetus at term equivalent age. Higher protein intake by these two individualized fortification regimens may improve growth outcomes without linear growth depression in extremely preterm infants.
|
| Free Research Field |
新生児医学
|
