Dynamic epigenetic change of keratinocytes in inflammtory skin diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461657
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Nagoya University
• Principal Investigator: Yasushi Ogawa 名古屋大学, 医学部附属病院, 助教 (10567754)
• Research Collaborator: AKIYAMA Masashi 名古屋大学, 大学院医学系研究科, 教授 (60222551)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 皮膚科学 / ケラチノサイト / エピジェネティクス / 乾癬

Outline of Final Research Achievements

This study aimed to investigate the roles of epigenetic changes of keratinocytes in the formation of inflammatory skin lesion of psoriasis. A reverse chemical genomics-approach was adopted. Topical imiquimod-induced skin inflammation was used as a mouse model of psoriasis, and various chemical inhibitors of chromatin modifying enzymes are applied to investigate their effect on the formation of the skin lesion. As a result we newly identified a histone demethylase inhibitor that promote the formation of the lesion, and a kinase inhibitor that suppress the skin lesion.

Free Research Field

皮膚科学