2016 Fiscal Year Final Research Report
The analysis of regulation of serine protease inhibitors expression in epidermal keratinocytes
| Project/Area Number |
26461658
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | セリンプロテアーゼ / セリンプロテアーゼ阻害因子 / 表皮角化細胞 |
|---|
| Outline of Final Research Achievements |
High calucium, TNF-alpha, IL-17A, and Toll-like receptor ligands significantly inudced the expression of LEKTI, SLPI, and elafin in normal human epidermal keratinocytes. In addition, high calcium up- and down-regulated trypsin- and chymotrypsin-like serine protease activities in epidermal keratinocytes, respectively.
Immunohistochemical analysis revealed that the expression of LEKTI, SLPI, and elafin were increased in the lesion of psoriasis, rosacea, acne, chronic pyoderma, and herpes zoster.
|
| Free Research Field |
皮膚自然免疫
|
