2016 Fiscal Year Final Research Report
The analysis of the mechanism of photoaging induced by the long-term UVA eye irradiation
| Project/Area Number |
26461667
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KASAHARA Emiko 大阪大学, 大学院薬学研究科, 特任助教 (30468269)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 紫外線 / 光老化 / 記憶・学習 |
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| Outline of Final Research Achievements |
Photoaging was induced using long-term ultraviolet (UV)A eye irradiation for 12 months. UVA eye irradiation increases the production of reactive oxygen species (ROS) from gp91phox in the brain, and this gp91phox-induced ROS stimulates urocortin 2. Moreover, urocortin 2 increases the degranulation of tryptase and histamine from mast cells of the skin, thereby leading to photoaging. On the other hand, our data suggested that long-term UVA eye irradiation results in depression of the memory and learning ability. The alteration similar to Alzheimer's disease occurs to the protein in the brain, and the introduction of glucose into the brain is additionally decreased. In addition, it was suggested that there is a close relation to photo aging, and memory and learning ability depression through a CRH/POMC system.
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| Free Research Field |
光生物学
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