2016 Fiscal Year Final Research Report
Investigation of subpopulation of skin resident macrophages.
Project/Area Number |
26461677
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
|
Research Institution | Tohoku University |
Principal Investigator |
Watabe Akiko 東北大学, 大学病院, 助教 (30422132)
|
Research Collaborator |
Kakizaki Aya 東北大学, 医学系研究科, 大学院生
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 腫瘍随伴性マクロファージ / ケモカイン / M2 マクロファージ / 腫瘍微小環境 |
Outline of Final Research Achievements |
In this study, we investigated the immunomodulatory effects of cancer-specific storma on tumor-associated macrophages, using skin samples from malignant melanoma, extramammary Paget's disease and cutaneous T cell lymphoma patients. Our study suggested that these skin cancer possesses different cancer storma (e.g. IL-4, periostin, RANKL, etc.), and those stromal factors stimulate macrophages to produce several specific chemokine, such as CCL17 and CCL22, to develop immunosuppressive tumor microenvironment in each tumor. Concerning inflammatory skin disease, we evaluated the immunomodulatory function of tissue-reside macrophages in pemphigus vulgaris and bullous pemphigoid, suggesting that the chemokine production from tissue-reside macrophages play important roles in developing autoimmune bullous disease.
|
Free Research Field |
皮膚科
|