2016 Fiscal Year Final Research Report
Function analysis of epidermal heme oxygenase-1 in selective knockout mice.
| Project/Area Number |
26461678
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | heme oxygenase-1 / ferroportin / 表皮細胞 |
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| Outline of Final Research Achievements |
We have been studying the role of heme oxygenase-1 (HO-1) in the epidermis. At the same time, we investigated the expression of ferroportin (Fpn), an iron transport membrane protein, in the murine epidermis and discovered that Fpn expression was induced as epithelial cells (EC) differentiate, which was correlated with HO-1 expression. To further investigate the role of both molecules in the epidermis, we created EC-specific HO-1-deficient mice and EC-specific Fpn-deficient mice. In the EC-specific HO-1-deficient mice, we found that the mice developed not only skin inflammation in the steady state but also weight loss. In the EC-specific Fpn-deficient mice gradually suffered from anemia. These results indicated that these two molecules affected the whole body condition as well as the epidermis. Further examination on the molecular basis of cooperation between these two molecules will provide the mechanism by which the skin metabolism affects the whole body metabolism.
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| Free Research Field |
皮膚科学
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