2016 Fiscal Year Final Research Report
The role of Syk in the pathogenesis of systemic sclerosis
| Project/Area Number |
26461680
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 全身性強皮症 / B細胞 / Syk |
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| Outline of Final Research Achievements |
Murine sclerodermatous chronic graft-versus-host disease (Scl-cGVHD) is a model for human Scl-cGVHD and systemic sclerosis (SSc). Syk is a protein tyrosine kinase that has an important role in transmitting signals from a variety of cell surface receptors.This study aims to investigate the effect of a Syk inhibitor, R788, on Scl-cGVHD and role of Syk in patients with SSc. Allogeneic BMT increased Syk phosphorylation in T, B, and CD11b+ cells. Early administration of Syk inhibitor attenuated severity and fibrosis of Scl-cGVHD. Syk inhibitor also reduced skin mRNA expressions of IL-13, IL-17A, and TGF-β1. However,Syk phosphorylation in B cell of SSc patients was not increased compared with that of normal control. The current studies suggested that Syk inhibitor is a potential candidate for use in treating patients with Scl-cGVHD and SSc.
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| Free Research Field |
皮膚科学
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