2016 Fiscal Year Final Research Report
Signal intensity can determine cell fate
| Project/Area Number |
26461683
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | Wnt signal / 悪性黒色腫 / 転移 / EMT / β-catenin |
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| Outline of Final Research Achievements |
We evaluated whether Wnt signal could induce metastasis of melanoma. β-catenin, a key component of Wnt signal, highly expressed at the tip of invading tumor, indicating that Wnt signal was activated in tumor cells in frontal tip of tumor. Melanoma cells, in which epithelial mesenchymal transition was induced by gene transfer showed weak cell adhesion and high mobility. To investigate the relationship between intensity of Wnt signal in melanoma cells and the potential of metastasis, we tried the establishment of system that allows the variable expression of β-catenin in melanoma cells. The system remained to be established. We will continue experiment and examine the experimental conditions.
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| Free Research Field |
皮膚腫瘍
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