2016 Fiscal Year Final Research Report
The role of plasmacutoid dendritic cells in the pathogenesis of alopecia areata
| Project/Area Number |
26461689
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Ito Taisuke 浜松医科大学, 医学部附属病院, 講師 (90293638)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 形質細胞様樹状細胞 / IFN-alpha / SiglecH / 円形脱毛症 / Chemerin |
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| Outline of Final Research Achievements |
Alopecia areata (AA) model mouse, C3H/HeJ mouse was employed in this study, Lymphonode cells from C3H/HeJ mouse with AA were activated with IL-2, IL-7 and IL-15 for 5 days. Then, these activated LN cells were intracutaneously injected into healthy C3H/HeJ mouse. The frequency of pDCs were significantly higher in non lesional skin in AA mouse. Furthermore, pDCs from spleen cells induced alopecia lesions in healthy C3H/HeJ mouse. PDCs might be important initiator of AA in C3H/HeJ mouse.
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| Free Research Field |
皮膚科学
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