Persistent release of IL-1s from skin causes systemic Inflammatory diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461690
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Mie University
• Principal Investigator: Yamanaka Keiichi 三重大学, 医学系研究科, 教授 (70314135)
• Co-Investigator(Kenkyū-buntansha): 水谷 仁 三重大学, 医学系研究科, リサーチアソシエイト (30115737)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: アトピー性皮膚炎 / 尋常性乾癬 / サイトカイン / 動脈硬化症 / 全身性アミロイドーシス

Outline of Final Research Achievements

The skin is an immune organ that produces large amount of proinflammatory cytokines including IL-1. The role of the epidermal IL-1 is not limited to initiation of local inflammatory responses, but also to induction of systemic inflammation. We here showed the occurrence of severe systemic cardiovascular diseases and metabolic abnormalities including aberrant vascular wall remodeling with aortic stenosis, cardiomegaly, impaired limb and tail circulation, fatty tissue loss and systemic amyloidsis in multiple organs in mouse models with severe dermatitis caused by persistent release of IL-1s from the skin. These morbid conditions were ameliorated by the administration of anti-IL-1α and IL-1β antibodies.

Free Research Field

慢性皮膚炎症