2017 Fiscal Year Final Research Report
Role of SLAM in the pathogenesis of atopic dermatitis and IgE induction
Project/Area Number |
26461691
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
|
Research Institution | Kyoto University |
Principal Investigator |
KITOH AKIHIKO 京都大学, 医学研究科, 講師 (40508438)
|
Co-Investigator(Renkei-kenkyūsha) |
NOMURA Takashi 京都大学, 医学研究科, 特定講師 (60346054)
|
Research Collaborator |
SHIBUYA Rintaro
HANAKAWA Sho
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Keywords | IgE |
Outline of Final Research Achievements |
The costimulatory molecule SLAM (CD150) is thought to be important for Th2 type immune reactions. However, the precise role of SLAM in chronic skin inflammation and IgE induction in atopic dermatitis, a typical Th2-related skin disease, is still unclear. Results of this study indicate that SLAM on T lymphocytes is involved in the IgE production associated with atopic dermatitis although SLAM plays only a minimal, if any, role in the development of atopic dermatitis.
|
Free Research Field |
皮膚科学
|