2016 Fiscal Year Final Research Report
Mechanism underlying the biological clock dysfunction-induced onset of mood disorder and hippocampal neurogenesis upregulation
| Project/Area Number |
26461709
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 時計遺伝子 / Clock / 気分障害 / 神経幹細胞 / 海馬ニューロン新生 |
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| Outline of Final Research Achievements |
It is well known that the circadian rhythm dysregulation is associated with onset of mood disorder in human. In this study, we investigated the effects of clock gene mutation on the hippocampal neurogenesis and tried to clarify the underlying molecular mechanism. We found that clock mutant showed the mania-like behaviour of mice and hypersensitivity to EGF of cultured neural stem cells. The detailed assay revealed that clock mutaion altered EGF-induced acute changes in clock-related genes as well as the cell cycle-related genes in the neural stem cells. These findings suggest that the molecular clock in the neural stem cells causally involve the onset of mood disorder via regulation the cell cycle conditions.
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| Free Research Field |
精神神経薬理学
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