2017 Fiscal Year Final Research Report
Identification of biological factors related to the pathological condition of postpartum depression using comprehensive epigenome analysis
| Project/Area Number |
26461717
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Ozaki Norio 名古屋大学, 医学系研究科, 教授 (40281480)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 網羅的メチル化解析 / 周産期 / うつ病 |
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| Outline of Final Research Achievements |
In this study, we conducted comprehensive methylation analysis using peripheral blood with the aim of developing a diagnostic method for postpartum depression (PPD). A total of 18 female cases and 18 female controls were enrolled. We performed a case-control study to examine the association of DNA methylation (DNAm) status (p＜1.3E-7). After that we conducted functional enrichment analysis of PPD. We observed no genome-wide significant association between the genome-wide measure of DNAm based on all CpG sites and PPD. From a result of comparing the case-control DNAm level, we selected 1,000 sites with low p-values and conducted functional enrichment analysis. As a result of enrichment analysis we found four GO Terms. From the results of this study, we confirmed that not only a single methylation site but also an analysis focusing on their functional relevance was useful for development of a diagnostic method for postpartum depression.
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| Free Research Field |
精神医学
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